Analysis of Drug-Drug Interactions with Cyclic Voltammetry: An Overview of Relevant Theoretical Models and Recent Experimental Achievements

Authors

  • Pavlinka Kokoskarova Faculty of Medical Sciences, Goce Delcev University, Stip, Macedonia
  • Rubin Gulaboski Faculty of Medical Sciences, Goce Delcev University, Stip, Macedonia
  • Sofija Petkovska
Abstract:

In this review, we focus on cyclic voltammetry as a reliable electrochemical technique to study mechanisms, kinetics and thermodynamics of various types of drug-drug interactions. While we present and discuss six theoretical models relevant to analyze drug-drug (or drug-DNA) interactions, we also give hints about recent experimental achievements in this field. In addition, we provide the readers several sets of simulated voltammograms and data in tabular form, which can be used to recognize particular mechanism of drug-drug interactions in cyclic voltammetry. Moreover, we give hints to the voltammetric procedures that allow access to kinetics and thermodynamics parameters, which are relevant to various types of drug-drug interactions. The results we present in this work can be of big help to the scientists working in the field of pharmacy, pharmacology, medicinal chemistry and bio-electrochemistry.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Toxicity of Nanoparticles and an Overview of Current Experimental Models

Nanotechnology is a rapidly growing field having potential applications in many areas. Nanoparticles (NPs) have been studied for cell toxicity, immunotoxicity, and genotoxicity. Tetrazolium-based assays such as MTT, MTS, and WST-1 are used to determine cell viability. Cell inflammatory response induced by NPs is checked by measuring inflammatory biomarkers, such as IL-8, IL-6, and tumor necrosi...

full text

comparative dna interaction studies of antiviral drug, zidovudine and its complex using different instrumental methods

هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...

15 صفحه اول

Drug-Drug Interactions: Influence of verapamil on the pharmacokinetics of sitagliptin in rats and Ex vivo models

P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) play a significant role in the disposition and elimination of drugs. The objective of this study was to investigate the mechanism underlying the interaction between sitagliptin (substrate of P-gp and CYP3A4) and verapamil (known modulator of P-gp and CYP3A4) using in vivo, ex vivo and in situ models. Rats were treated with sitagliptin (10 m...

full text

A theoretical study on interactions between Berberine as an anticancer drug and DNA

In this study, we present the work on the physicochemical interaction between the anti-cancer alkaloidberberine (BRB) and DNA with the purpose of designing drugs that interact more with DNA. Molecularmodeling on the complex formed between berberine and DNA presented that this complex was undeniablyfully able of participating in the formation of a stable intercalation site. Besides, the molecula...

full text

Involvement of cytochromes p450 in drug-drug interactions: an overview.

Drug interactions can cause iatrogenic disease. If concurrent medications are taken, the potential exists for a drug interaction to occur. Renewed interest in the topic interactions has been generated by the fatal interactions involving non-sedating histamine H-1 antagonists and the recent intriduction of two therapeutic agents, the selective serotonin reuptake inhibitors (SSRIs) and HIV protea...

full text

An Investigation of Drug Interactions in Hospital Pharmacy Prescriptions

Drug therapy is a complex and important process and because of the importance of drug interactions, especially in in-patients, accompanying problems and obstacles would exist as a result of concomitant use of drugs in these patients. For this purpose 3130 prescription order forms from Bou-Ali hospital were collected and all potential drug interactions presentwere extracted and evaluated in term...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 12  issue 3

pages  345- 364

publication date 2020-03-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023